Bridging Scales: a Hybrid Model to Simulate Vascular Tumor Growth and Treatment Response.

Cancer is a disease driven by random DNA mutations and the interaction of many complex phenomena. To improve the understanding and ultimately find more effective treatments, researchers leverage computer simulations mimicking the tumor growth in silico. The challenge here is to account for the many phenomena influencing the disease progression and treatment protocols. This work introduces a computational model to simulate vascular tumor growth and the response to drug treatments in 3D. It consists of two agent-based models for the tumor cells and the vasculature. Moreover, partial differential equations govern the diffusive dynamics of the nutrients, the vascular endothelial growth factor, and two cancer drugs. The model focuses explicitly on breast cancer cells over-expressing HER2 receptors and a treatment combining standard chemotherapy (Doxorubicin) and monoclonal antibodies with anti-angiogenic properties (Trastuzumab). However, large parts of the model generalize to other scenarios. We show that the model qualitatively captures the effects of the combination therapy by comparing our simulation results with previously published pre-clinical data. Furthermore, we demonstrate the scalability of the model and the associated C++ code by simulating a vascular tumor occupying a volume of 400mm3 using a total of 92.5 million agents.

Spiking Neural Network for Fourier Transform and Object Detection for Automotive Radar.

The development of advanced autonomous driving applications is hindered by the complex temporal structure of sensory data, as well as by the limited computational and energy resources of their on-board systems. Currently, neuromorphic engineering is a rapidly growing field that aims to design information processing systems similar to the human brain by leveraging novel algorithms based on spiking neural networks (SNNs). These systems are well-suited to recognize temporal patterns in data while maintaining a low energy consumption and offering highly parallel architectures for fast computation. However, the lack of effective algorithms for SNNs impedes their wide usage in mobile robot applications. This paper addresses the problem of radar signal processing by introducing a novel SNN that substitutes the discrete Fourier transform and constant false-alarm rate algorithm for raw radar data, where the weights and architecture of the SNN are derived from the original algorithms. We demonstrate that our proposed SNN can achieve competitive results compared to that of the original algorithms in simulated driving scenarios while retaining its spike-based nature.